Differential cardiac impacts of hematological malignancies and solid tumors: a histopathological and biomarker study
This study demonstrates that HM patients have fewer cardiomyocyte nuclei and poorly aligned collagen, with serum biomarker evidence of increased cardiac dysfunction. This supports the necessity for specialized cardiac care for these patients.
Authors
- Umesh C. Sharma (ORCID: https://orcid.org/0000-0003-0476-2523)
- Sharma Kattel (ORCID: https://orcid.org/0000-0002-9088-2654)
- Michael Udin (ORCID: https://orcid.org/0009-0006-9465-3919)
- Amr Abdelradi (ORCID: https://orcid.org/0000-0001-6902-675X)
- Scott Doyle
- Sarmila Nepali (ORCID: https://orcid.org/0000-0002-2384-421X)
- Sunitha Shyam Sunder (ORCID: https://orcid.org/0000-0002-8167-0369)
- Ciprian N. Ionita (ORCID: https://orcid.org/0000-0001-7049-0592)
- Qian Liu (ORCID: https://orcid.org/0000-0002-6986-5542)
- Saraswati Pokharel (ORCID: https://orcid.org/0000-0002-4104-462X)
Institutions
- Roswell Park Comprehensive Cancer Center (US)
- University of Minnesota (US)
- Canon (United States) (US)
- University at Buffalo, State University of New York (US)
Publication Details
- Journal
- Cardio-Oncology
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1186/s40959-024-00285-3
- Citations
- 4
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- National Cancer Institute