Proteoglycan 4 (Lubricin) and regulation of xanthine oxidase in synovial macrophage as a mechanism of controlling synovitis
PRG4 is a biologically significant modulator of synovial homeostasis via inhibition of XO expression and downstream HIF-1a activation. PRG4 signaling is anti-inflammatory and promotes synovial homeostasis in chronic synovitis, where direct XO inhibition is potentially therapeutic in chronic synovitis.
Authors
- Tannin A. Schmidt (ORCID: https://orcid.org/0000-0001-7140-254X)
- Thomas Zhao
- Gregory D. Jay (ORCID: https://orcid.org/0000-0003-1517-8488)
- Khaled A. Elsaid (ORCID: https://orcid.org/0000-0002-8925-4255)
- Ling X. Zhang
- Derek Jenkins
- Ava Marks
Institutions
- University of Connecticut (US)
- Chapman University (US)
- Providence College (US)
- Brown University (US)
- Rhode Island Hospital (US)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s13075-024-03455-x
- Citations
- 4
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 1.14