Transforming growth factor-beta is increased in sputum from individuals with rheumatoid arthritis-associated pulmonary fibrosis
We demonstrate that sputum levels of TGF-β are significantly elevated in individuals with RA-PF, correlate with lung disease severity, and are elevated in those with the MUC5B ILD-risk polymorphism. These findings could identify novel approaches to ILD screening in RA and potential targeted therapeutic strategies for RA-ILD.
Authors
- Kevin D. Deane (ORCID: https://orcid.org/0000-0003-2211-4861)
- Joshua J. Solomon (ORCID: https://orcid.org/0000-0001-5488-4874)
- Peter B. Sachs (ORCID: https://orcid.org/0000-0003-3555-1497)
- M. Kristen Demoruelle (ORCID: https://orcid.org/0000-0002-2563-5155)
- Timothy M. Wilson (ORCID: https://orcid.org/0000-0003-2989-133X)
- Andrew Stahly
- Stephen M. Humphries (ORCID: https://orcid.org/0000-0002-5113-4530)
- Matthew Bolt (ORCID: https://orcid.org/0000-0003-2032-4021)
- Joyce Lee (ORCID: https://orcid.org/0000-0002-5758-8365)
- Tami J. Bang
Institutions
- Thomas Jefferson University (US)
- National Jewish Health (US)
- University of Colorado Anschutz Medical Campus (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Lara D. Veeken
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1093/rheumatology/keae697
- Citations
- 4
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- Pfizer
- Rheumatology Research Foundation
- National Institutes of Health