A high polygenic risk score is associated with SSA/SSB antibody positivity and early onset in primary Sjögren’s disease
A high PRS is associated with SSA/SSB antibody positivity and early disease onset, both largely attributed to the weight of the HLA alleles. Integration of PRS with other biomarkers applied to clinical phenotypes could be a useful tool for disease risk stratification and treatment decisions.
Authors
- Janicke Liaaen Jensen (ORCID: https://orcid.org/0000-0003-4276-9611)
- Sara Magnusson Bucher
- Cecilia Fugmann
- Pascal Pucholt (ORCID: https://orcid.org/0000-0003-3342-1373)
- Juliana Imgenberg‐Kreuz (ORCID: https://orcid.org/0000-0002-7230-8990)
- Øyvind Palm (ORCID: https://orcid.org/0000-0001-5395-0665)
- Silke Appel (ORCID: https://orcid.org/0000-0002-2199-2315)
- Svein Joar Auglænd Johnsen (ORCID: https://orcid.org/0000-0002-1591-9250)
- Peter Olsson (ORCID: https://orcid.org/0000-0002-9846-5257)
- Christopher Sjöwall (ORCID: https://orcid.org/0000-0003-0900-2048)
- Gunnel Nordmark (ORCID: https://orcid.org/0000-0002-3829-7431)
- Katrine Brække Norheim (ORCID: https://orcid.org/0000-0002-3770-8139)
- Marie Wahren‐Herlenius (ORCID: https://orcid.org/0000-0002-0915-7245)
- Marika Kvarnström (ORCID: https://orcid.org/0000-0002-4948-8380)
- Helena Forsblad‐d’Elia (ORCID: https://orcid.org/0000-0001-7871-5303)
- Roland Jonsson (ORCID: https://orcid.org/0000-0002-9588-0260)
- Johannes Mofors (ORCID: https://orcid.org/0000-0003-1873-7169)
- Sarah Reid (ORCID: https://orcid.org/0000-0003-4065-6875)
- Dag Leonard (ORCID: https://orcid.org/0000-0002-6275-7282)
- Daniel Hammenfors
- Roald Omdal (ORCID: https://orcid.org/0000-0002-6051-4658)
- Thomas Mandl (ORCID: https://orcid.org/0000-0002-7143-7088)
- Per Eriksson (ORCID: https://orcid.org/0000-0002-3555-7162)
- Albin Björk
- Eva Baecklund (ORCID: https://orcid.org/0000-0001-5033-0188)
Institutions
- Linköping University (SE)
- Uppsala University (SE)
- Oslo University Hospital (NO)
- University of Oslo (NO)
- Lund University (SE)
- Örebro University (SE)
- Stavanger University Hospital (NO)
- Science for Life Laboratory (SE)
- Haukeland University Hospital (NO)
- Karolinska Institutet (SE)
- Skåne University Hospital (SE)
- Center for Rheumatology (US)
- University of Bergen (NO)
- University of Gothenburg (SE)
Publication Details
- Journal
- Lara D. Veeken
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1093/rheumatology/keae693
- Citations
- 5
- Primary Topic
- Salivary Gland Disorders and Functions
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- Wellcome Trust
- Hjärt-Lungfonden
- Karolinska Institutet
- Knut och Alice Wallenbergs Stiftelse
- Stockholms Läns Landsting
- Vetenskapsrådet
- Norges Forskningsråd
- Akademiska Sjukhuset
- Uppsala Universitet
- Stiftelsen Konung Gustaf V:s 80-årsfond
- Reumatikerförbundet
- Science for Life Laboratory
- Uppsala Multidisciplinary Center for Advanced Computational Science