How well do plasma Alzheimer’s disease biomarkers reflect the CSF amyloid status?
There was variable performance of plasma biomarkers to recapitulate the CSF assay. Both p-tau217 and p-tau217/Aβ42 showed excellent promise as surrogates of CSF amyloid status, although with slightly reduced performance in older individuals. There was poorer discriminatory ability for p-tau181 and Aβ42/40. Further research is needed to address potential age-related confounds.
Authors
- Nick C. Fox (ORCID: https://orcid.org/0000-0002-6660-657X)
- Ivo Laranjinha (ORCID: https://orcid.org/0000-0001-5895-0680)
- Robert Howard (ORCID: https://orcid.org/0000-0002-3071-2338)
- Jonathan M. Schott (ORCID: https://orcid.org/0000-0003-2059-024X)
- Miguel L. Grilo (ORCID: https://orcid.org/0000-0001-7364-821X)
- Emily K. Abel (ORCID: https://orcid.org/0000-0002-0328-901X)
- Jemma Hazan (ORCID: https://orcid.org/0000-0002-7223-4768)
- Amanda Heslegrave (ORCID: https://orcid.org/0000-0002-7290-6405)
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0003-3930-4354)
- Kathy Y Liu (ORCID: https://orcid.org/0000-0002-7482-2758)
- Deborah O T Alawode (ORCID: https://orcid.org/0000-0002-0024-3147)
Institutions
- Sahlgrenska University Hospital (SE)
- University College Lahore (PK)
- Swedish Academy (SE)
- University College of Osteopathy (GB)
- UK Dementia Research Institute (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
- University of Gothenburg (SE)
Publication Details
- Journal
- Journal of Neurology Neurosurgery & Psychiatry
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1136/jnnp-2024-334122
- Citations
- 4
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 1.54
Funders
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- Familjen Erling-Perssons Stiftelse
- Cure Alzheimer's Fund
- Stiftelsen för Gamla Tjänarinnor
- EU Joint Programme – Neurodegenerative Disease Research
- National Institute for Health and Care Research
- European Commission
- Rosetrees Trust
- Hjärnfonden
- Vetenskapsrådet
- University College London Hospitals NHS Foundation Trust
- UK Dementia Research Institute
- HORIZON EUROPE Framework Programme
- Medical Research Council