LAT4 drives temozolomide induced radiotherapy resistance in glioblastoma by enhancing mTOR pathway activation
Our study links tumor sensitivity to chemotherapy and radiotherapy and highlights the critical role of LAT4 in activating the mTOR pathway and GBM radiotherapy resistance. It suggests ways to improve radiotherapy sensitivity to GBM.
Authors
- Yifeng Huang
- Jiajun Zheng (ORCID: https://orcid.org/0000-0001-7292-2678)
- Jingjing Zhao (ORCID: https://orcid.org/0000-0002-9880-508X)
- Yuntao Lu (ORCID: https://orcid.org/0000-0003-4125-304X)
- Junjie Li (ORCID: https://orcid.org/0000-0002-4862-2517)
- Wanling Zhang (ORCID: https://orcid.org/0000-0001-5154-3097)
- Chiyang Li
- Lei Chen (ORCID: https://orcid.org/0009-0009-1979-211X)
- Y. Liu (ORCID: https://orcid.org/0009-0006-7331-7959)
- Yanjie Xu (ORCID: https://orcid.org/0000-0002-6038-0266)
- Qiang Zhou (ORCID: https://orcid.org/0000-0001-8632-7554)
- Yongfu Cao
- Wenrui Zang
- Zhenyuan Wang
Institutions
- Nanfang Hospital (CN)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s12935-024-03590-0
- Citations
- 1
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- National Natural Science Foundation of China
- Guangdong Medical Research Foundation
- Southern Medical University
- Nanfang Hospital
- Guangdong Provincial People's Hospital