Mendelian randomization and mediation examination of the immune cell-mediated link between sphingomyelin and stroke
We confirmed the effect of sphingomyelin on stroke and conducted in-depth studies. SSC-A on CD8br and CD45 on CD8br is latent stroke mediators associated with sphingomyelin. Through two-step mediated Mendelian randomization analysis, we provide new insights into the etiology and treatment of stroke.
Authors
- Jianglei Ma (ORCID: https://orcid.org/0000-0002-2770-7597)
- Cong Xu
- Yonghong Xu
- Guangming Wang (ORCID: https://orcid.org/0009-0008-3946-3578)
Institutions
- Dali University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Stroke and Cerebrovascular Diseases
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1016/j.jstrokecerebrovasdis.2024.108205
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Dali University