CD34+ Orbital Fibroblasts Contribute to the Pathogenesis of Thyroid Eye Disease via miR-182-5p
The IL-6/STAT3/miR-182-5p pathway led to activation of CD34+ OFs. MiR-182-5p promoted the proliferation, migration, fibrosis, and anti-apoptosis of CD34+ OFs via targeting Smad7. Our findings suggest that miR-182-5p may potentially serve as a therapeutic target for TED.
Authors
- Yang Wang (ORCID: https://orcid.org/0000-0001-6125-183X)
- Chenfang Zhu
- Huifang Zhou (ORCID: https://orcid.org/0000-0002-8636-861X)
- Bin Yu (ORCID: https://orcid.org/0000-0001-7683-9943)
- Sijie Fang (ORCID: https://orcid.org/0000-0003-1423-4820)
- Jun‐O Jin (ORCID: https://orcid.org/0000-0003-4216-8111)
- Jing Sun (ORCID: https://orcid.org/0000-0001-6284-7862)
- Bin Li (ORCID: https://orcid.org/0009-0008-3791-0936)
- Dan Li (ORCID: https://orcid.org/0000-0003-4770-1034)
- Yinwei Li (ORCID: https://orcid.org/0000-0002-9974-504X)
- Yazhuo Huang
- Jin Liu (ORCID: https://orcid.org/0000-0002-2026-2513)
- Yi Wang (ORCID: https://orcid.org/0009-0004-0665-5945)
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Ninth People's Hospital (CN)
- Institute of Immunology (HR)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1210/clinem/dgae876
- Citations
- 7
- Primary Topic
- Fibroblast Growth Factor Research
- Type
- article
- Field-Weighted Citation Impact
- 1.64
Funders
- National Natural Science Foundation of China