Patterns and Cofactors of Polyfunctional Mycobacteria-Specific T-Cell Response Restoration Following 6-Month Antiretroviral Treatment in Children With HIV
Despite increases in Th1 cytokine production, deficits in mycobacteria-specific CD4 cells persisted 6 months after ART, with higher deficits in older CHIV with more immunosuppression, higher immune activation, and lower proportion of naive CD4 cells. These findings may explain persistent TB risk during early ART among CHIV and identify those at highest risk.
Authors
- Irene N Njuguna (ORCID: https://orcid.org/0000-0003-4250-3231)
- Elizabeth Maleche‐Obimbo (ORCID: https://orcid.org/0000-0001-7871-3367)
- Dalton C. Wamalwa (ORCID: https://orcid.org/0000-0002-5510-462X)
- Hellen Moraa (ORCID: https://orcid.org/0000-0001-8862-3058)
- Alessandro Sette (ORCID: https://orcid.org/0000-0001-7013-2250)
- Loren E. Sasser (ORCID: https://orcid.org/0000-0003-3348-9933)
- Cyrus Mugo (ORCID: https://orcid.org/0000-0001-7516-2168)
- Jaclyn N Escudero (ORCID: https://orcid.org/0000-0002-3513-774X)
- Cheryl L. Day
- Wendy Whatney
- Sylvia M. LaCourse (ORCID: https://orcid.org/0000-0002-9809-5997)
- Grace C. John-Stewart (ORCID: https://orcid.org/0000-0002-4301-1573)
- Lisa M. Cranmer (ORCID: https://orcid.org/0000-0002-6938-9195)
- Cecilia S. Lindestam Arlehamn (ORCID: https://orcid.org/0000-0001-7302-8002)
- Rachel A Pearson (ORCID: https://orcid.org/0000-0003-3957-1524)
Institutions
- Statens Serum Institut (DK)
- University of Nairobi (KE)
- La Jolla Institute for Immunology (US)
- Emory University (US)
- University of Washington (US)
- Kenyatta National Hospital (KE)
- University of California San Diego (US)
- Institute of Child Health (IN)
- Children's Healthcare of Atlanta (US)
- Atlanta VA Medical Center (US)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1093/infdis/jiae630
- Citations
- 1
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.29