Overcoming the Silencing of Doxycycline-Inducible Promoters in hiPSC-derived Cardiomyocytes
These findings underscore the need for integrating multiple strategies, including careful GSH selection, improved cassette design, epigenetic modulation, and clone screening, to develop robust dox-inducible systems that retain functionality during hiPSC differentiation.
Authors
- Elisa Balmas (ORCID: https://orcid.org/0000-0002-4600-6809)
- Alessandro Bertero (ORCID: https://orcid.org/0000-0002-4919-9087)
- Sveva Bottini
- Michelle Guichardaz
Institutions
- University of Turin (IT)
Publication Details
- Journal
- Open Research Europe
- Published
- 2024-12-18
- DOI
- https://doi.org/10.12688/openreseurope.19024.1
- Citations
- 4
- Primary Topic
- RNA Interference and Gene Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Giovanni Armenise-Harvard Foundation
- Ministero dell'Università e della Ricerca
- HORIZON EUROPE Framework Programme