Integrating genetic and clinical data to predict lung cancer in patients with chronic obstructive pulmonary disease
The rs56113850 (risk allele C) in CYP2A6, decrease in BMI, increase in pack-years and emphysema presence were independent risk factors for LC in COPD. Integrating genetic and clinical data for predicting LC in COPD demonstrated favorable predictive performance.
Authors
- Fengzhi Yu
- Jijia Sun (ORCID: https://orcid.org/0000-0001-5068-4357)
- Lixin Wang (ORCID: https://orcid.org/0000-0003-4748-3225)
- Yonghui Wu
- Gu Zhan (ORCID: https://orcid.org/0000-0002-4018-3505)
Institutions
- Tongji University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Shanghai Pulmonary Hospital (CN)
Publication Details
- Journal
- BMC Pulmonary Medicine
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s12890-024-03444-5
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China