Bortezomib induces Rho-dependent hyperpermeability of endothelial cells synergistically with inflammatory mediators
Our findings suggest that BTZ accumulates RhoA and RhoC proteins in endothelial cells, amplifying the inflammatory mediator-induced increase in the active GTP-bound state of Rho, thereby exaggerating vascular permeability during pulmonary inflammation. This study provides novel insights into the molecular mechanism underlying the pulmonary complications of BTZ, suggesting that BTZ may enhance inflammatory responses in pulmonary endothelial cells by increasing RhoA and RhoC protein levels.
Authors
- Akihiko Gemma (ORCID: https://orcid.org/0000-0003-0762-2737)
- Takeru Kashiwada
- Koichiro Kamio (ORCID: https://orcid.org/0000-0002-6870-9548)
- Shunichi Nishima
- Kuniko Matsuda
- Shinya Yuge
- Tomohiro Ishii (ORCID: https://orcid.org/0000-0003-3092-1401)
- Masahiro Seike (ORCID: https://orcid.org/0000-0002-1572-5472)
- Shigetomo Fukuhara (ORCID: https://orcid.org/0000-0003-2777-501X)
- Yoshinobu Saito (ORCID: https://orcid.org/0000-0001-9630-8066)
Institutions
- Nippon Medical School (JP)
Publication Details
- Journal
- BMC Pulmonary Medicine
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s12890-024-03387-x
- Citations
- 1
- Primary Topic
- Multiple Myeloma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.45
Funders
- Japan Society for the Promotion of Science