Sparstolonin B potentiates the antitumor activity of nanovesicle-loaded drugs by suppressing the phagocytosis of macrophages in vivo
The TLR2 pathway plays a crucial role in the sequestration of NVs by Mφs. A novel antiphagocytic strategy in which pretreatment of mice with SpB inhibits the clearance of NVs and prolongs their half-life in vivo, thereby improving delivery efficiency, was identified.
Authors
- Kaihuan Yu (ORCID: https://orcid.org/0000-0001-9235-7848)
- Zuo Mou
- Xiaoqin He (ORCID: https://orcid.org/0000-0003-0319-9345)
- Zhekai Wang
- X. Mao (ORCID: https://orcid.org/0009-0001-3091-6816)
- Yang Shen (ORCID: https://orcid.org/0000-0002-4682-4852)
- Wei Wang (ORCID: https://orcid.org/0000-0002-5386-9530)
- Wei Song (ORCID: https://orcid.org/0000-0002-8512-0663)
- Yuefeng Zhang (ORCID: https://orcid.org/0000-0002-3364-7762)
- Yangtao Xu (ORCID: https://orcid.org/0009-0001-4404-6110)
- Yi Qin (ORCID: https://orcid.org/0000-0002-7515-5918)
- Peng Ma (ORCID: https://orcid.org/0009-0009-4720-5322)
Institutions
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s12951-024-03001-6
- Citations
- 2
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- National Natural Science Foundation of China
- Wuhan University