Annotated interictal discharges in intracranial EEG sleep data and related machine learning detection scheme

Interictal epileptiform discharges (IEDs) such as spikes and sharp waves represent pathological electrophysiological activities occurring in epilepsy patients between seizures. IEDs occur preferentially during non-rapid eye movement (NREM) sleep and are associated with impaired memory and cognition. Despite growing interest, most studies involving IED detections rely on visual annotations or employ simple amplitude threshold approaches. Alternatively, advanced computerized detection methods are not standardized or publicly available. To address this gap, we introduce a novel dataset comprising multichannel intracranial electroencephalography (iEEG) data recorded at two medical centers during overnight sleep with IED annotations performed by expert neurologists. Utilizing these annotations to train machine learning models via a gradient-boosting algorithm, we demonstrate automated IED detection with high precision (94.4%) and sensitivity (94.3%) that can generalize across individuals and surpass performance of a leading commercial software. The dataset featuring multi-channel annotations with sub-second resolution including hippocampus and medial temporal lobe (MTL) regions is made publicly available, together with the detection algorithm, to advance research on detection methodology, epilepsy, sleep, and cognition.