Mitochondria-targeted antioxidant mitoquinone mitigates vitrification-induced damage in mouse ovarian tissue by maintaining mitochondrial homeostasis via the p38 MAPK pathway
MitoQ effectively mitigates vitrification-induced oxidative damage, maintains mitochondrial homeostasis, and preserves both follicular reserve and endocrine function. These findings suggest that MitoQ is a valuable adjunct in ovarian tissue cryopreservation and could significantly improve fertility preservation outcomes for cancer patients.
Authors
- Tianqi Du (ORCID: https://orcid.org/0000-0002-1894-9607)
- Hong Li (ORCID: https://orcid.org/0009-0006-1296-5071)
- Zhenxing Liu (ORCID: https://orcid.org/0000-0003-1173-0044)
- Ming Zhang (ORCID: https://orcid.org/0000-0003-4574-9704)
- Qingxia Meng (ORCID: https://orcid.org/0009-0005-0666-7425)
- Dan Cao (ORCID: https://orcid.org/0000-0003-3612-0074)
- Han Su (ORCID: https://orcid.org/0009-0005-4957-6750)
Institutions
- Suzhou Municipal Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s40001-024-02181-z
- Citations
- 5
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 1.17