Astragaloside IV attenuates podocyte apoptosis via regulating TXNIP/NLRP3/GSDMD signaling pathway in diabetic nephropathy
The anti-pyroptosis effect of AS-IV via the TXNIP-NLRP3-GSDMD axis improves the renal function and podocyte damage of db/db mice and delays the onset of DKD, according to in vivo and in vitro experimental data.
Authors
- Gao Cai-ling
- Junfen Liu
- Congqing Pan (ORCID: https://orcid.org/0000-0001-6532-4928)
- Jun Guo (ORCID: https://orcid.org/0000-0001-9867-2689)
- Zhibo Hu
- Yu Zhou (ORCID: https://orcid.org/0000-0003-3230-8395)
Institutions
- Tianjin Medical University (CN)
Publication Details
- Journal
- Diabetology & Metabolic Syndrome
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s13098-024-01546-y
- Citations
- 9
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.10
Funders
- Tianjin Municipal Health Commission
- Tianjin Medical University