Deciphering the synergistic role of tyrosyl-tRNA synthetase 1 and yes-associated protein 1: Catalysts of malignant progression in hepatocellular carcinoma
In summary, this research reveals that YARS1 enhances the malignant progression of HCC through the activation of the YAP1 signaling pathway. Elevated levels of YARS1 in HCC are strongly linked to poor prognosis, indicating that YARS1 might serve as a new therapeutic target for HCC. Future studies should investigate additional mechanisms of YARS1 in HCC and create targeted therapies to improve outcomes for HCC patients.
Authors
- Lifang Zhou (ORCID: https://orcid.org/0000-0002-9663-298X)
- Jiaju Zhang (ORCID: https://orcid.org/0000-0002-7957-3156)
- Xin Zhang (ORCID: https://orcid.org/0000-0003-4298-7926)
- Yunxia Wang (ORCID: https://orcid.org/0009-0006-5357-5125)
- Chongyang Zhang (ORCID: https://orcid.org/0000-0001-7325-7200)
- Yutong Sui
- Yu Wang (ORCID: https://orcid.org/0000-0002-8159-8723)
Institutions
- Cangzhou Central Hospital (CN)
- People's Hospital of Cangzhou (CN)
Publication Details
- Journal
- CytoJournal
- Published
- 2024-12-18
- DOI
- https://doi.org/10.25259/cytojournal_91_2024
- Citations
- 6
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 1.96