Integrating bioinformatics and machine learning to uncover lncRNA LINC00269 as a key regulator in Parkinson's disease via pyroptosis pathways
This study identifies LINC00269 as a potential contributor to pyroptosis pathways in PD. While further investigation is required to fully elucidate its role, these findings provide new insights into PD pathogenesis and suggest potential avenues for future research on diagnostic and therapeutic targets. The study underscores the importance of integrating bioinformatics with experimental validation in neurodegenerative disease research.
Authors
- Yue Liu (ORCID: https://orcid.org/0009-0007-8136-6627)
- Hongjia Zhang (ORCID: https://orcid.org/0009-0001-8585-208X)
- Na Mi (ORCID: https://orcid.org/0000-0002-2937-5880)
- Xiuzhi Xu (ORCID: https://orcid.org/0009-0007-6575-016X)
- Ying Tang (ORCID: https://orcid.org/0000-0002-2027-5955)
- Lili Ma (ORCID: https://orcid.org/0000-0001-9617-9954)
- Jing Fang (ORCID: https://orcid.org/0000-0003-4157-8303)
- Rui Bao
- Yajing Ren
Institutions
- Harbin Medical University (CN)
- Heilongjiang University of Chinese Medicine (CN)
- Jilin City Central Hospital (CN)
- Chifeng Municipal Hospital (CN)
- Fourth Affiliated Hospital of Harbin Medical University (CN)
- Chengdu University (CN)
- Heilongjiang Provincial Hospital (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s40001-024-02201-y
- Citations
- 2
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.57
Funders
- Harbin Medical University
- National Natural Science Foundation of China
- Department of Education, Heilongjiang Province
- Natural Science Foundation of Heilongjiang Province