Two highly selected mutations in the tandemly duplicated CYP6P4a and CYP6P4b genes drive pyrethroid resistance in Anopheles funestus in West Africa
Overall, this study demonstrated that CYP6P4a and CYP6P4b contribute to pyrethroid resistance in An. funestus and provided two additional insecticide resistance molecular diagnostic tools that would contribute to monitoring and better management of resistance.
Authors
- Sulaiman S. Ibrahim (ORCID: https://orcid.org/0000-0003-0744-802X)
- Derrick Neba Nebangwa (ORCID: https://orcid.org/0000-0002-5815-5705)
- Charles S. Wondji (ORCID: https://orcid.org/0000-0003-0791-3673)
- Magellan Tchouakui (ORCID: https://orcid.org/0000-0002-1683-8057)
- Theofelix A. Tekoh (ORCID: https://orcid.org/0009-0009-1781-782X)
- Mersimine Kouamo (ORCID: https://orcid.org/0000-0003-0170-9516)
- Stephen Mbigha Ghogomu (ORCID: https://orcid.org/0000-0003-3459-6554)
- Carlos S. Djoko Tagne (ORCID: https://orcid.org/0000-0002-4752-5344)
- Leon M. J. Mugenzi (ORCID: https://orcid.org/0000-0002-6857-9608)
- Abdullahi Muhammad (ORCID: https://orcid.org/0000-0002-6438-4897)
- Nelly M.T. Tatchou-Nebangwa (ORCID: https://orcid.org/0000-0003-2988-1190)
Institutions
- University of Buea (CM)
- King's College London (GB)
- Liverpool School of Tropical Medicine (GB)
- University of Bamenda (CM)
- Ministry of Scientific Research and Innovation (CM)
- Syngenta (Switzerland) (CH)
- Bayero University Kano (NG)
Publication Details
- Journal
- BMC Biology
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s12915-024-02081-y
- Citations
- 13
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 7.06
Funders
- Bill and Melinda Gates Foundation
- Wellcome Trust
- Darwin Trust of Edinburgh