cfDNA fragmentation patterns correlate with tumor burden measured via PSMA PET/CT volumetric parameters in patients with biochemical recurrence of prostate cancer
This prospective study demonstrated a statistically significant negative correlation between cfDNA fragmentation patterns and PSMA PET/CT volumetric parameters in patients with presumed localized prostate cancer with early biochemical recurrence. These findings underscore the potential of liquid biopsy as a biomarker and a complementary tool to PSMA PET/CT to assess disease progression during the follow-up of these patients.
Authors
- Sergi Vidal‐Sicart (ORCID: https://orcid.org/0000-0002-6303-3606)
- María J. Ribal (ORCID: https://orcid.org/0000-0001-8142-5382)
- Joel Mases (ORCID: https://orcid.org/0000-0002-7991-7932)
- Amparo Cobo
- Aida Niñerola
- Inmaculada Romero‐Zayas (ORCID: https://orcid.org/0000-0003-1972-284X)
- Pilar Paredes
- Andrés Perissinotti (ORCID: https://orcid.org/0000-0003-4190-2425)
- Xavier Setoaín
- Katherine Quintero (ORCID: https://orcid.org/0000-0002-5642-3905)
- Lourdes Mengual (ORCID: https://orcid.org/0000-0001-7418-9422)
- Fiorella L. Roldán (ORCID: https://orcid.org/0000-0002-9152-922X)
- Sebastián Casanueva-Eliceiry (ORCID: https://orcid.org/0000-0002-5539-5850)
- Mercedes Ingelmo‐Torres (ORCID: https://orcid.org/0000-0002-7116-2045)
- África Muxí
- Laura Izquierdo (ORCID: https://orcid.org/0000-0001-6015-2987)
- David Fuster (ORCID: https://orcid.org/0000-0003-0906-0627)
- Antonio Alcaraz (ORCID: https://orcid.org/0000-0003-2612-5250)
- Francisco Campos (ORCID: https://orcid.org/0000-0001-9046-8050)
- Gary Amseian (ORCID: https://orcid.org/0009-0005-5464-1342)
- Marcel Figueras (ORCID: https://orcid.org/0000-0001-5846-7277)
- Mercè Moragas
- Rita Pages
- Rocío Caratini
Institutions
- Hospital Clínic de Barcelona (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- EJNMMI Research
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s13550-024-01170-x
- Citations
- 2
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.84