Efficacy, safety, and biomarker analysis of first-line immune checkpoint inhibitors with chemotherapy versus chemotherapy for advanced gastric cancer: a multicenter, retrospective cohort study
Adding ICIs to first-line treatment significantly prolongs survival in overall patients and in those with PD-L1 CPS 1-4 or unknown. This study also provides valuable insights into prognostic markers and resistance mechanisms, potentially guiding immunotherapy strategies.
Authors
- Jianyuan Zhou
- Xinyu Song (ORCID: https://orcid.org/0000-0002-3861-1320)
- Zimin Liu (ORCID: https://orcid.org/0000-0003-3104-4287)
- Xin Dai (ORCID: https://orcid.org/0000-0002-0472-700X)
- Zhaodi Nan
- Linli Qu
- Li Song (ORCID: https://orcid.org/0000-0003-3502-3803)
- Yi Zhai (ORCID: https://orcid.org/0000-0001-5726-104X)
- Lian Liu (ORCID: https://orcid.org/0000-0001-5868-4482)
- Meili Sun (ORCID: https://orcid.org/0000-0002-4914-6508)
- Cong Lei (ORCID: https://orcid.org/0009-0009-0981-9614)
- Di Zhang (ORCID: https://orcid.org/0000-0002-2342-5779)
- Qiushi Wang (ORCID: https://orcid.org/0000-0002-6491-064X)
- Xue Zhang (ORCID: https://orcid.org/0000-0002-8179-138X)
- Zhen Li (ORCID: https://orcid.org/0000-0001-5524-895X)
- Jing Liang (ORCID: https://orcid.org/0000-0003-0811-0223)
- Lu Yue (ORCID: https://orcid.org/0000-0002-2392-1860)
- Miao Huang (ORCID: https://orcid.org/0000-0002-7912-916X)
- Haiyan Liu (ORCID: https://orcid.org/0000-0002-4961-4252)
- Jing Lv (ORCID: https://orcid.org/0000-0003-2801-743X)
- Jinling Zhang (ORCID: https://orcid.org/0000-0002-6017-7751)
- Jiahui Chu (ORCID: https://orcid.org/0000-0003-2949-1491)
- Qian Xu (ORCID: https://orcid.org/0000-0001-7061-7282)
- Aina Liu (ORCID: https://orcid.org/0000-0002-2038-5820)
- Ruitao Xu
- Fangli Cao
- Shulun Nie
- Fujun Yang
- Shuang Wang
Institutions
- Qingdao University (CN)
- Shandong University (CN)
- Yuhuangding Hospital (CN)
- Linyi People's Hospital (CN)
- Second Hospital of Shandong University (CN)
- Jinan Central Hospital (CN)
- Shandong Provincial Hospital (CN)
- Affiliated Hospital of Qingdao University (CN)
- Qingdao Municipal Hospital (CN)
- Weihai Municipal Hospital (CN)
- Central Hospital of Zibo (CN)
- Affiliated Hospital of Shandong University of Traditional Chinese Medicine (CN)
- Qilu Hospital of Shandong University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s12916-024-03801-5
- Citations
- 9
- Primary Topic
- Gastric Cancer Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 3.77
Funders
- National Natural Science Foundation of China