Updated and revised Russian consensus on the use of multilevel injections of abobotulinumtoxin A in children
One of the modern components of complex rehabilitation of patients with spasticity is the use of botulinum toxin type A (BTA) preparations. International experience with the use of botulinum therapy in children spans more than 30 years. Abobotulinum toxin A has been used to treat spasticity since 1994. Clinical studies have shown the high efficacy of abobotulinumtoxin A in relieving spasticity of the lower and upper extremities in cerebral palsy (CP) and other disorders, which is associated with a significant increase in muscle tone, thereby increasing motor skills and achieving individual patient goals. The article presents a consensus of Russian experts on the approach to selecting target muscles and calculating the dose of abobotulinumtoxin A in multilevel injections, and discusses the planning of repeat injections, ethical and legal aspects of botulinum therapy in children, the combination of botulinum therapy with other methods of correcting spasticity in CP, the use of BTA in dystonia and sialorrhea, and factors potentially influencing the effectiveness of botulinum therapy. This consensus summarizes the views of Russian experts on creating an injection protocol depending on individual clinical data and treatment goals, which can be used as a guide for practical work.
Authors
- Il'ya V. Fal'kovskiy
- D. M. Dankov (ORCID: https://orcid.org/0000-0003-1526-8723)
- O. N. Vasil’eva (ORCID: https://orcid.org/0000-0002-7188-7185)
- O. A. Klochkova (ORCID: https://orcid.org/0000-0002-4079-3450)
- М. Н. Буторина (ORCID: https://orcid.org/0000-0003-1545-9044)
- Б. И. Бурсагова (ORCID: https://orcid.org/0000-0001-8506-2064)
- O. G. Dontzov
- A. M. Mamedyarov (ORCID: https://orcid.org/0000-0003-0818-6906)
- Dmitry Popkov (ORCID: https://orcid.org/0000-0002-8996-867X)
- Leyla Seymurovna Namazova-Baranova (ORCID: https://orcid.org/0000-0002-2209-7531)
- Vladimir Markovich Kenis (ORCID: https://orcid.org/0000-0002-7651-8485)
- Л. М. Кузенкова (ORCID: https://orcid.org/0000-0002-9562-3774)
- Х. М. Каримова (ORCID: https://orcid.org/0000-0001-6560-9552)
- Л. В. Рычкова (ORCID: https://orcid.org/0000-0002-0117-2563)
- A. L. Kurenkov
- Olga Е. Agranovich (ORCID: https://orcid.org/0000-0002-6655-4108)
- T.V. Kiseleva
- В. П. Зыков (ORCID: https://orcid.org/0000-0002-1401-5479)
- A. S. Nosko (ORCID: https://orcid.org/0000-0003-4426-9573)
- Diana Krasavina (ORCID: https://orcid.org/0000-0003-4255-7029)
- V. A. Zmanovskaya (ORCID: https://orcid.org/0000-0002-1742-1907)
- E. V. Levitina (ORCID: https://orcid.org/0000-0003-2553-7552)
- S. O. Ryabykh
- V. I. Michnovich (ORCID: https://orcid.org/0000-0003-4994-8508)
- T. A. Belogorova
- M. A. Ryzhenkov
- L. N. Vladykina
Institutions
- Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics (RU)
- Pirogov Russian National Research Medical University (RU)
- Nemours Children’s Clinic (US)
- Center for Children (US)
- Ministry of Health of the Russian Federation (RU)
- Scientific Center of Family Health Problems and Human Reproduction (RU)
- The Turner Scientific Research Institute for Children's Orthopedics (RU)
- Stavropol State Medical University (RU)
- Tyumen State Medical University (RU)
- Saint Petersburg State Pediatric Medical University (RU)
Publication Details
- Journal
- Neurology neuropsychiatry Psychosomatics
- Published
- 2024-12-18
- DOI
- https://doi.org/10.14412/2074-2711-2024-6-125-133
- Citations
- 1
- Primary Topic
- Botulinum Toxin and Related Neurological Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.37