The association of HDL-cholesterol levels with incident major adverse cardiovascular events and mortality in 0.6 million individuals with type 2 diabetes: a population-based retrospective cohort study
Our study demonstrated a U-shaped association between HDL-C levels and incident MACEs and all-cause and non-cardiovascular mortality in individuals with type 2 diabetes, highlighting the need for mechanistic studies on the adverse outcomes seen at high HDL-C levels in type 2 diabetes.
Authors
- David Tak Wai Lui (ORCID: https://orcid.org/0000-0002-9813-1126)
- Chi‐Ho Lee (ORCID: https://orcid.org/0000-0002-7569-409X)
- Yu Cho Woo
- Xi Xiong (ORCID: https://orcid.org/0000-0002-9418-7448)
- Kathryn Choon Beng Tan (ORCID: https://orcid.org/0000-0001-9037-0416)
- Carlos King Ho Wong (ORCID: https://orcid.org/0000-0002-6895-6071)
- Eric Ho Man Tang (ORCID: https://orcid.org/0000-0003-4196-8686)
- Brian Hung‐Hin Lang (ORCID: https://orcid.org/0000-0002-9362-0086)
- Xiaodong Liu (ORCID: https://orcid.org/0000-0002-2592-8310)
- Lanlan Li (ORCID: https://orcid.org/0009-0002-5529-5830)
Institutions
- Department of Health (CN)
- Chinese University of Hong Kong (HK)
- London School of Hygiene & Tropical Medicine (GB)
- HKU-Pasteur Research Pole (HK)
- Laboratory of Data Discovery for Health (HK)
- University College London (GB)
- University of Hong Kong (HK)
Publication Details
- Journal
- BMC Medicine
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s12916-024-03810-4
- Citations
- 11
- Primary Topic
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Type
- article
- Field-Weighted Citation Impact
- 3.93
Funders
- Innovation and Technology Commission
- Hospital Authority
- Hong Kong Government
- Li Ka Shing Faculty of Medicine, University of Hong Kong