Microglial CD2AP deficiency exerts protection in an Alzheimer’s disease model of amyloidosis
Our results demonstrate that CD2AP regulates microgliosis and identify a protective function of microglial CD2AP deficiency against Aβ deposition, suggesting the importance of detailed investigation of AD-associated genes in different brain cells for thoroughly understanding their exact contribution to AD.
Authors
- Lingliang Zhang
- Naizhen Zheng
- Yunqiang Zhou
- Yun‐wu Zhang (ORCID: https://orcid.org/0000-0002-7152-7630)
- Jian Meng (ORCID: https://orcid.org/0000-0003-0848-0830)
- Tiantian Guo
- Yuanhui Huo
- Honghua Zheng (ORCID: https://orcid.org/0000-0001-7589-2646)
- Yingjun Zhao (ORCID: https://orcid.org/0000-0003-2832-6590)
- Xiaofeng Chen (ORCID: https://orcid.org/0000-0002-3591-8001)
- Liang Zhang (ORCID: https://orcid.org/0000-0002-2279-2657)
- Zijie Wang (ORCID: https://orcid.org/0000-0002-6246-2812)
- Shanshan Zhao (ORCID: https://orcid.org/0000-0003-2690-0624)
- Lingyi Huang
- Yinan Zhou (ORCID: https://orcid.org/0009-0009-0973-1612)
- David M. Holtzman
Institutions
- Xiamen University (CN)
- First Affiliated Hospital of Xiamen University (CN)
- Hope Center for Neurological Disorders (US)
Publication Details
- Journal
- Molecular Neurodegeneration
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s13024-024-00789-7
- Citations
- 9
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.23
Funders
- National Natural Science Foundation of China
- Fundamental Research Funds for the Central Universities