myCAF-derived exosomal PWAR6 accelerates CRC liver metastasis via altering glutamine availability and NK cell function in the tumor microenvironment
myCAFs derived exosomes PWAR6 represents a pivotal marker for CRC liver metastasis, and its targeted inhibition with ASO-PWAR6, in combination with FAPI treatment, effectively curtails metastasis in preclinical models, offering promising therapeutic potential for clinical management.
Authors
- Ruiqi Gu
- Jin Li (ORCID: https://orcid.org/0000-0002-4325-9691)
- Guoxiang Cai (ORCID: https://orcid.org/0000-0002-7772-7078)
- Hongsheng Fang
- Wenqin Luo (ORCID: https://orcid.org/0000-0002-2486-807X)
- Weixing Dai (ORCID: https://orcid.org/0000-0002-5395-8568)
- Shanyou Tong (ORCID: https://orcid.org/0000-0002-2363-9339)
- Lei Han (ORCID: https://orcid.org/0000-0001-6007-9716)
- Yichao Wang (ORCID: https://orcid.org/0000-0002-3456-0765)
- Xue Wang (ORCID: https://orcid.org/0000-0002-0423-1952)
- Yanbo Zhang (ORCID: https://orcid.org/0000-0002-2421-157X)
- Renjie Wang
- Chengyao Jiang
Institutions
- Shanghai Medical College of Fudan University (CN)
- Shanghai Jiao Tong University (CN)
- Fudan University Shanghai Cancer Center (CN)
- Shanghai First People's Hospital (CN)
Publication Details
- Journal
- Journal of Hematology & Oncology
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s13045-024-01643-5
- Citations
- 25
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 5.85
Funders
- National Natural Science Foundation of China