Stratified Medicine Pediatrics: Cell-Free DNA and Serial Tumor Sequencing Identifies Subtype-Specific Cancer Evolution and Epigenetic States
In tumors of childhood, we identify mutations in epigenetic genes as drivers of relapse, with matched cfDNA sequencing showing significant intratumor genetic heterogeneity and cell-state specific patterns of chromatin accessibility. This highlights the power of cfDNA analysis to identify both genetic and epigenetic drivers of aggressive disease in pediatric cancers.
Authors
- JANET M. SHIPLEY (ORCID: https://orcid.org/0000-0001-6748-8678)
- John A. Anderson (ORCID: https://orcid.org/0000-0001-7509-3203)
- Ama Brew (ORCID: https://orcid.org/0009-0001-2090-9348)
- G.A. Amos Burke (ORCID: https://orcid.org/0000-0003-2671-9972)
- Aditi Vedi (ORCID: https://orcid.org/0000-0001-6761-6510)
- Bissan Al‐Lazikani (ORCID: https://orcid.org/0000-0003-3367-2519)
- Paula Proszek (ORCID: https://orcid.org/0000-0002-0780-6790)
- Jane Chalker
- Darren Hargrave (ORCID: https://orcid.org/0000-0001-8219-9807)
- Reda Stankunaite (ORCID: https://orcid.org/0000-0003-3977-7020)
- Sara Stoneham (ORCID: https://orcid.org/0000-0001-5482-648X)
- Milind Ronghe (ORCID: https://orcid.org/0000-0002-1865-9335)
- Tony Rogers (ORCID: https://orcid.org/0009-0009-1194-3542)
- Quentin Campbell-Hewson (ORCID: https://orcid.org/0000-0003-1509-6925)
- Josef H. Vormoor (ORCID: https://orcid.org/0000-0002-1825-1890)
- Juliet C. Gray (ORCID: https://orcid.org/0000-0002-5652-4722)
- Chris Jones (ORCID: https://orcid.org/0000-0001-8118-2296)
- Michael Hubank (ORCID: https://orcid.org/0000-0002-2901-0742)
- Guy Makin (ORCID: https://orcid.org/0000-0003-3513-3957)
- Jennifer Turnbull (ORCID: https://orcid.org/0009-0001-4066-5571)
- Trevor A. Graham (ORCID: https://orcid.org/0000-0001-9582-1597)
- Andrea Sottoriva (ORCID: https://orcid.org/0000-0001-6709-9533)
- Lina Yuan (ORCID: https://orcid.org/0000-0002-2873-5565)
- Lisa Howell (ORCID: https://orcid.org/0000-0003-2119-2630)
- Carolin M. Sauer (ORCID: https://orcid.org/0000-0003-2168-6630)
- Helen Rees
- J. Ciaran Hutchinson (ORCID: https://orcid.org/0000-0002-1708-2634)
- Deborah A. Tweddle (ORCID: https://orcid.org/0000-0003-2208-3970)
- Susanne A. Gatz (ORCID: https://orcid.org/0000-0002-6438-9778)
- Pamela R. Kearns (ORCID: https://orcid.org/0000-0003-2756-5813)
- Sally L. George (ORCID: https://orcid.org/0000-0003-2777-4922)
- Courtney Willis (ORCID: https://orcid.org/0009-0008-3829-8363)
- George D. Cresswell (ORCID: https://orcid.org/0000-0003-3303-068X)
- Louis Chesler (ORCID: https://orcid.org/0000-0001-7842-2068)
- Richard Guy Grundy (ORCID: https://orcid.org/0000-0002-2585-2539)
- Thomas S. Jacques (ORCID: https://orcid.org/0000-0002-7833-2158)
- Jennifer Tall
- Steven C. Clifford (ORCID: https://orcid.org/0000-0003-4893-2184)
- Sabri Jamal (ORCID: https://orcid.org/0000-0002-2444-9633)
- Debbie Hughes
- Emma Ross (ORCID: https://orcid.org/0000-0002-1179-0592)
- Minou Oostveen (ORCID: https://orcid.org/0000-0001-9674-8870)
- Lynley V. Marshall (ORCID: https://orcid.org/0000-0002-6537-2118)
- Angela Jesudason (ORCID: https://orcid.org/0000-0002-9278-1304)
- Claire Lynn (ORCID: https://orcid.org/0000-0002-2630-4075)
- Isidro Cortés‐Ciriano (ORCID: https://orcid.org/0000-0002-2036-494X)
- Paola Angelini (ORCID: https://orcid.org/0000-0001-5930-3530)
- Madeleine Adams (ORCID: https://orcid.org/0000-0001-6169-1149)
- Robert E. Johnston
- Martin J. Elliott (ORCID: https://orcid.org/0000-0002-0167-9700)
- Victoria Lee (ORCID: https://orcid.org/0000-0003-2244-4756)
- Saira Waqar Ahmed (ORCID: https://orcid.org/0009-0005-2565-7417)
- Shaun Wilson (ORCID: https://orcid.org/0000-0002-3825-6525)
- Ridwan Shaikh (ORCID: https://orcid.org/0009-0003-9179-0748)
Institutions
- University College Hospital (GB)
- Leeds General Infirmary (GB)
- European Bioinformatics Institute (GB)
- Royal Marsden NHS Foundation Trust (GB)
- The University of Texas MD Anderson Cancer Center (US)
- Institute of Cancer Research (GB)
- University of Liverpool (GB)
- Great Ormond Street Hospital (GB)
- Leicester Royal Infirmary (GB)
- Great Ormond Street Hospital for Children NHS Foundation Trust (GB)
- Royal Hospital for Children (GB)
- Royal Belfast Hospital for Sick Children (GB)
- Cancer Research UK (GB)
- Southampton General Hospital (GB)
- Bristol Royal Hospital for Children (GB)
- Cambridge University Hospitals NHS Foundation Trust (GB)
- John Radcliffe Hospital (GB)
- University of Manchester (GB)
- Birmingham Children's Hospital (GB)
- Brain Tumour Research (GB)
- Royal Aberdeen Children's Hospital (GB)
- Royal Hospital for Sick Children (GB)
- Noah's Ark Children's Hospital for Wales (GB)
- Human Technopole (IT)
- Cancer Research Institute of the Slovak Academy of Sciences (SK)
- Royal Marsden Hospital (GB)
- St Anna Children's Hospital (AT)
- Princess Máxima Center (NL)
- Cancer Research UK Clinical Trials Unit (GB)
- Queen's Medical Centre (GB)
- Great North Children's Hospital (GB)
- The London College (GB)
- Oxford University Hospitals NHS Trust (GB)
- Alder Hey Children's Hospital (GB)
- Royal Manchester Children's Hospital (GB)
- Sheffield Children's Hospital (GB)
- University of Southampton (GB)
- St. Anna Children's Cancer Research Institute
- University College London (GB)
- University of Birmingham (GB)
- Newcastle University (GB)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1158/2159-8290.cd-24-0916
- Citations
- 7
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 2.00
Funders
- AstraZeneca
- Wellcome Trust
- Cancer Research UK
- CHILDREN with CANCER UK
- Associazione Italiana per la Ricerca sul Cancro
- Genentech
- Imperial Experimental Cancer Medicine Centre
- H2020 Marie Skłodowska-Curie Actions