Clinical and Proteomic Risk Profiles of New-Onset Heart Failure in Men and Women
In men and women, the most prominent risk factors for new-onset HF were hypertension and obesity, but they conferred a greater risk of new-onset HF in women. New-onset HF in both men and women was associated with pathophysiological pathways related to neutrophil degranulation and immunomodulation; and these pathways partly mediated the association between hypertension, obesity, and new-onset HF.
Authors
- Geert H.D. Voordes (ORCID: https://orcid.org/0000-0001-8403-0562)
- Camilla C.S. van der Hoef (ORCID: https://orcid.org/0009-0006-2091-1911)
- Hailun Qin (ORCID: https://orcid.org/0000-0002-7267-3162)
- Bart J. van Essen (ORCID: https://orcid.org/0000-0002-9057-7449)
- Adriaan A. Voors
- Bernadet T. Santema (ORCID: https://orcid.org/0000-0002-4663-7213)
- Jasper Tromp (ORCID: https://orcid.org/0000-0001-6043-0713)
- Jozine M. ter Maaten (ORCID: https://orcid.org/0000-0002-4910-9336)
- Mark André de la Rambelje (ORCID: https://orcid.org/0009-0002-4083-0087)
Institutions
- University Medical Center Groningen (NL)
- University of Groningen (NL)
- National University Health System (SG)
Publication Details
- Journal
- JACC Heart Failure
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1016/j.jchf.2024.09.022
- Citations
- 12
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 4.82