Engineering a controllable and reversible switch for CAR-based cellular immunotherapies via a genetic code expansion system
Our study systematically demonstrated that the BOCK-induced genetic code expansion system effectively and precisely regulates CAR protein expression and controls CAR-T cell anti-tumor effects in vitro and in vivo. We conclude that this controllable and reversible switch has the potential for more effective, secure, and clinically available CAR-based cellular immunotherapies.
Authors
- Wen Qin (ORCID: https://orcid.org/0000-0002-2714-3613)
- Lingna An
- Xiaoqi Wang (ORCID: https://orcid.org/0000-0001-8251-9102)
- Yue Liu (ORCID: https://orcid.org/0000-0002-0092-7485)
- Xi Zhang (ORCID: https://orcid.org/0000-0002-0422-8980)
- Cheng Zhang (ORCID: https://orcid.org/0000-0002-0024-7324)
- Yueyu Dai (ORCID: https://orcid.org/0000-0001-8705-9432)
Institutions
- Army Medical University (CN)
- Chongqing University (CN)
- Xinqiao Hospital (CN)
- Chongqing University of Technology (CN)
Publication Details
- Journal
- Journal of Hematology & Oncology
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s13045-024-01648-0
- Citations
- 7
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 1.98
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Chongqing
- Chongqing Municipal Education Commission
- Army Medical University
- Centre Scientifique et Technique du Bâtiment