Reception of damage and activation of growth of connective tissue: crucial regulatory milestones of regeneration in humans

Tissue damage activates programs aimed at the survivalof the body and restoration of its integrity, but fora long time the molecular and cellular mechanisms of theirimplementation remained undeciphered. In recent years, a number of importantinformation has been obtained about the regulation of regeneration processes,which significantly clarify a number of ideas about the regulationof the response to damage and deserve attention in termsof searching for new targets for controlling this process. Thisreview briefly summarizes the basic regulatory mechanisms associated with theearly stages of the human tissue response to injury. Italso provides current data on the mechanisms of damage receptionand the role of stromal cells in the formation ofprimary connective tissue as a structure that determines the outcome.