Synergistic enhancement of low-dose radiation therapy via cuproptosis and metabolic reprogramming for radiosensitization in in situ hepatocellular carcinoma
In conclusion, this study elucidates the intricate interactions among tumor hypoxia reversal, cuproptosis, metabolic reprogramming, and radiosensitization, particularly in the context of treating in situ hepatocellular carcinoma, thereby providing a novel paradigm for radiotherapy.
Authors
- Genwen Hu (ORCID: https://orcid.org/0000-0002-7032-7581)
- Jifeng Chen (ORCID: https://orcid.org/0009-0009-2438-8314)
- Zeyu Xiao (ORCID: https://orcid.org/0000-0003-2220-5675)
- Ni Shao
- Yanyu Huang (ORCID: https://orcid.org/0000-0002-4134-944X)
- Hong Zhang
- Qiao Luo (ORCID: https://orcid.org/0000-0002-2483-6035)
- Nianlan Cheng
- Liangping Luo (ORCID: https://orcid.org/0000-0002-7312-5782)
- Yongqing Yang
Institutions
- Jinan University (CN)
- First Affiliated Hospital of Jinan University (CN)
- University of California, Davis (US)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1186/s12951-024-03011-4
- Citations
- 14
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 3.99
Funders
- National Natural Science Foundation of China
- Jinan University
- Guangzhou Municipal Science and Technology Project
- Basic and Applied Basic Research Foundation of Guangdong Province