Infiltrative classical monocyte-derived and SPP1 lipid-associated macrophages mediate inflammation and fibrosis in ANCA-associated glomerulonephritis
Our findings highlight the expression of inflammatory and fibrotic genes by kidney macrophage subsets in AGN. Classical monocyte dysregulation might contribute to inflammation in the pathogenesis of AGN. Targeting these specific monocyte/macrophage subsets may potentially control the inflammatory cascade and attenuate resulting fibrosis in AGN and kidney disease in general.
Authors
- Nike Claessen
- Koen H.M. Prange (ORCID: https://orcid.org/0000-0002-9835-1735)
- Aldo Jongejan (ORCID: https://orcid.org/0000-0002-8948-2549)
- Fréderike J. Bemelman (ORCID: https://orcid.org/0000-0002-4454-6270)
- Jesper Kers (ORCID: https://orcid.org/0000-0002-2418-5279)
- Marc L. Hilhorst (ORCID: https://orcid.org/0000-0003-3712-7171)
- Perry D. Moerland (ORCID: https://orcid.org/0000-0002-2357-3659)
- Yosta Vegting (ORCID: https://orcid.org/0000-0002-1909-8461)
- Liffert Vogt (ORCID: https://orcid.org/0000-0002-4585-7505)
- Menno P.J. de Winther (ORCID: https://orcid.org/0000-0002-4038-6636)
- Ester B. M. Remmerswaal (ORCID: https://orcid.org/0000-0003-4694-6048)
- Annette E. Neele (ORCID: https://orcid.org/0000-0001-9029-3991)
- Onno J. de Boer (ORCID: https://orcid.org/0000-0001-8844-1326)
- Joris J. T. H. Roelofs (ORCID: https://orcid.org/0000-0001-9595-6571)
- Gal Sela
- Joost W van der Heijden
Institutions
- Leiden University Medical Center (NL)
- Spaarne Ziekenhuis (NL)
- Amsterdam Neuroscience (NL)
- GGD Amsterdam (NL)
- Public Health Service of Amsterdam (NL)
- Amsterdam University Medical Centers (NL)
- Spaarne Gasthuis (NL)
- Institute of Infection and Immunity (CA)
- Amsterdam University of Applied Sciences (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Nephrology Dialysis Transplantation
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1093/ndt/gfae292
- Citations
- 11
- Primary Topic
- Vasculitis and related conditions
- Type
- article
- Field-Weighted Citation Impact
- 4.61
Funders
- Nierstichting
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Ministry of Minority Affairs