H and B Blood Antigens Are Essential for In Vitro Replication of GII.2 Human Norovirus
The findings of this study suggests that GII.2 and GII.17 VLPs may be advantageous as HuNoV vaccine candidates because they elicit neutralizing antibodies against the predominant GII.4 genotype, which could be particularly beneficial for infants without prior HuNoV exposure. These insights will contribute to the development of effective HuNoV vaccines.
Authors
- Yu Takahashi (ORCID: https://orcid.org/0000-0003-3186-2925)
- Yuhki Koike
- Keiichi Uchida (ORCID: https://orcid.org/0000-0003-2272-3755)
- Naomi Sakon (ORCID: https://orcid.org/0000-0001-7521-9654)
- Naomi Matsumoto (ORCID: https://orcid.org/0000-0002-9980-6092)
- Shintaro Sato (ORCID: https://orcid.org/0000-0001-5156-3354)
- Shigeyuki Tamiya
- Mikihiro Inoue (ORCID: https://orcid.org/0000-0003-4573-0405)
- Shiho Kurokawa
- Hiroshi Ushijima (ORCID: https://orcid.org/0000-0003-4378-3861)
- Yutaka Nakamura (ORCID: https://orcid.org/0000-0001-8717-1475)
- Yoshikazu Yuki (ORCID: https://orcid.org/0000-0001-6574-9184)
- Hiroshi Kiyono (ORCID: https://orcid.org/0000-0001-7307-4658)
Institutions
- Nihon University (JP)
- Tokyo University of Agriculture (JP)
- Fujita Health University (JP)
- Chiba University (JP)
- Mie University (JP)
- Wakayama Medical University (JP)
- University of California San Diego (US)
- Chiba University Hospital (JP)
- Osaka Prefectural Institute of Public Health (JP)
- Osaka International Cancer Institute (JP)
- The University of Tokyo (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1093/ofid/ofae714
- Citations
- 2
- Primary Topic
- Viral gastroenteritis research and epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.78
Funders
- University of Wyoming
- Japan Agency for Medical Research and Development
- Ministry of Health, Labour and Welfare
- Japan Society for the Promotion of Science