Disruption of Epithelial Barrier Integrity via Altered GILZ/c-Rel/RACK1 Signaling in Inflammatory Bowel Disease
We provide the first evidence that an alteration of RACK1/SRC/E-cadherin regulatory mechanism, correlating with decreased GILZ protein expression, is involved in epithelial barrier disruption. The clinical relevance is based on the fact that this mechanism involving GILZ/c-Rel-related RACK1 expression could be considered to improve IBD therapies, particularly in patients with low or no response to glucocorticoid treatment.
Authors
- Marco Vincenzo Lenti (ORCID: https://orcid.org/0000-0002-6654-4911)
- Simona Ronchetti (ORCID: https://orcid.org/0000-0002-5639-4243)
- Lucrezia Rosati
- Eleonora Lusenti
- Francesca Fagiani (ORCID: https://orcid.org/0000-0001-7722-0624)
- Marco Racchi (ORCID: https://orcid.org/0000-0002-7185-7808)
- Marco Gentili (ORCID: https://orcid.org/0000-0002-2305-4488)
- Luigi Cari (ORCID: https://orcid.org/0000-0003-0698-3872)
- Erica Buoso (ORCID: https://orcid.org/0000-0003-1728-0443)
- Stefan Alexander Przyborski (ORCID: https://orcid.org/0000-0001-7613-525X)
- Mirco Masi (ORCID: https://orcid.org/0000-0003-0919-5206)
- Alessandra Pasini (ORCID: https://orcid.org/0000-0002-2768-6263)
- Cristina Travelli (ORCID: https://orcid.org/0000-0002-9721-9572)
- Giorgia Colombo (ORCID: https://orcid.org/0000-0002-8280-2589)
- Federica Pisati
- Antonio Di Sabatino (ORCID: https://orcid.org/0000-0002-0302-8645)
- Chiara Oliviero
- Claire L. Mobbs (ORCID: https://orcid.org/0000-0003-0218-8062)
- Roberta Valeria Limosani
Institutions
- Boston University (US)
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- Optech (Canada) (CA)
- Vita-Salute San Raffaele University (IT)
- Durham University (GB)
- University of Pavia (IT)
- University of Perugia (IT)
- Istituto Universitario di Studi Superiori di Pavia (IT)
- Policlinico San Matteo Fondazione (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Piedmont University (US)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
Publication Details
- Journal
- Journal of Crohn s and Colitis
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1093/ecco-jcc/jjae191
- Citations
- 4
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 2.20
Funders
- Servier