Use of tenofovir-based preexposure prophylaxis among pregnant women in South Africa
We observed low-pregnancy incidence. Counselling may have encouraged delayed pregnancy plans; some women may have exaggerated pregnancy plans to enroll. About half of pregnant women used PrEP and took over half of doses by pillcap. Fewer than 25% had tenofovir detected, likely reflecting pregnancy-related pharmacokinetics and adherence challenges. High interest in pregnancy PrEP use highlights the need to optimize adherence support and prevention choice.
Authors
- John Bassler (ORCID: https://orcid.org/0000-0003-2277-9388)
- Manjeetha Jaggernath
- Christina Psaros (ORCID: https://orcid.org/0000-0002-0705-2239)
- Jennifer Smit (ORCID: https://orcid.org/0000-0003-4992-0900)
- Katia J. Bruxvoort (ORCID: https://orcid.org/0000-0001-8277-2431)
- Yolandie Kriel (ORCID: https://orcid.org/0000-0003-3910-4045)
- Jessica E. Haberer (ORCID: https://orcid.org/0000-0001-5845-3190)
- David R. Bangsberg (ORCID: https://orcid.org/0000-0002-6352-8908)
- Lynn T. Matthews (ORCID: https://orcid.org/0000-0001-6167-6328)
- Kara K. Bennett (ORCID: https://orcid.org/0000-0002-9465-8983)
- Patricia M. Smith (ORCID: https://orcid.org/0000-0003-4686-224X)
- Kathleen Wirth Hurwitz
Institutions
- Target (United States) (US)
- Lynn University (US)
- University of the Witwatersrand (ZA)
- University of Alabama at Birmingham (US)
- Massachusetts General Hospital (US)
Publication Details
- Journal
- AIDS
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1097/qad.0000000000004090
- Primary Topic
- HIV/AIDS Research and Interventions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Massachusetts General Hospital
- Gilead Sciences
- Andrew and Jaime Sullivan Family Foundation
- National Institutes of Health