Blocking IL1RAP on cancer-associated fibroblasts in pancreatic ductal adenocarcinoma suppresses IL-1-induced neutrophil recruitment
Our study demonstrates that targeting IL1RAP on CAFs inhibits IL-1-induced chemokine secretion and recruitment of neutrophils and monocytes, thereby counteracting the immunosuppressive microenvironment in PDAC. These findings highlight the therapeutic potential of targeting IL1RAP in PDAC.
Authors
- Marcus Järås (ORCID: https://orcid.org/0000-0003-4080-7055)
- Susanne Larsson Faria
- Katrin Reinbach
- Finja C. Hansen
- Susanne Magnusson
- Kawther Abdilleh (ORCID: https://orcid.org/0009-0001-5316-9366)
- Caitríona Grönberg (ORCID: https://orcid.org/0009-0000-3776-5566)
- Pablo Peña‐Martínez (ORCID: https://orcid.org/0000-0002-0789-6431)
- Karin von Wachenfeldt (ORCID: https://orcid.org/0000-0003-0579-2484)
- Camilla Rydberg Millrud (ORCID: https://orcid.org/0000-0002-5873-2197)
- Petter Skoog (ORCID: https://orcid.org/0009-0008-5621-3095)
- David Liberg (ORCID: https://orcid.org/0009-0009-0645-746X)
- Nils Hansen (ORCID: https://orcid.org/0009-0007-4556-5557)
Institutions
- Lund University (SE)
- Pancreatic Cancer Action Network (US)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1136/jitc-2024-009523
- Citations
- 12
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 3.39
Funders
- Cancerfonden
- Vetenskapsrådet
- Lund University Medical Faculty Foundation