Interleukin 8-CXCR2–mediated neutrophil extracellular trap formation in biliary atresia associated with neutrophil extracellular trap–induced stellate cell activation
Patients with BA have persistent IL-8-CXCR2-mediated NETosis that correlates with biomarkers of injury and fibrosis, and NETs induce stellate cell activation, suggesting a role for NETs in the immunopathogenesis of disease. Future investigations should focus on therapeutic agents that inhibit NETs in BA.
Authors
- Phillip Rosenthal
- Nitika Gupta (ORCID: https://orcid.org/0000-0002-6171-4731)
- Sarah A. Taylor (ORCID: https://orcid.org/0000-0002-3575-8386)
- Ronald J. Sokol (ORCID: https://orcid.org/0000-0001-7433-4095)
- Alexander Gerhard Miethke (ORCID: https://orcid.org/0000-0003-1395-9475)
- Pamela L. Valentino (ORCID: https://orcid.org/0000-0002-8227-2004)
- Cara L. Mack (ORCID: https://orcid.org/0000-0002-5760-3836)
- Lisa M. Fraser
- Jean Pappas Molleston (ORCID: https://orcid.org/0000-0002-8708-0298)
- Estella M. Alonso (ORCID: https://orcid.org/0000-0002-4056-7752)
- Yuhuan Luo
- Simon Horslen (ORCID: https://orcid.org/0000-0001-5949-7363)
- John C. Magee (ORCID: https://orcid.org/0000-0001-8416-7905)
- Kathleen M. Loomes (ORCID: https://orcid.org/0000-0002-1539-6672)
- Binita Maya Kamath (ORCID: https://orcid.org/0000-0002-9982-5023)
- Rohit Kohli (ORCID: https://orcid.org/0000-0002-0198-7703)
- Stephen L. Guthery
- Julia Jezykowski
Institutions
- Northwestern University (US)
- University of Southern California (US)
- Children's Hospital of Philadelphia (US)
- Emory University (US)
- University of Pittsburgh (US)
- University of California, San Francisco (US)
- University of Toronto (CA)
- University of Washington (US)
- Medical College of Wisconsin (US)
- University of Utah (US)
- University of Michigan (US)
- Hospital for Sick Children (CA)
- Riley Hospital for Children (US)
- SickKids Foundation (CA)
- University of Colorado Anschutz Medical Campus (US)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- Hepatology
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1097/hep.0000000000001195
- Citations
- 9
- Primary Topic
- Congenital Diaphragmatic Hernia Studies
- Type
- article
- Field-Weighted Citation Impact
- 5.15
Funders
- Cystic Fibrosis Foundation
- Sanofi
- American Association for the Study of Liver Diseases
- Gilead Sciences
- Ipsen
- Grifols
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases