CD69+CD103+CD8+ tissue-resident memory T cells possess stronger anti-tumor activity and predict better prognosis in colorectal cancer
We clarified the roles and mechanisms of different CD8<sup>+</sup> TRM subsets in CRC and identified that DP CD8<sup>+</sup> TRM cells exert stronger anti-tumor effects and predict better prognosis, which provides ideas for developing new clinically available therapeutic targets.
Authors
- Zhe-Xiong Lian
- Zixin Wu (ORCID: https://orcid.org/0009-0007-7792-4921)
- Tian-Tian Da
- Jie Long (ORCID: https://orcid.org/0000-0002-3016-3906)
- Hai-Qing Ma
- Tingting Yin (ORCID: https://orcid.org/0000-0002-1987-220X)
- Chuan Huang (ORCID: https://orcid.org/0000-0001-6052-0663)
- Zhi-Bin Zhao (ORCID: https://orcid.org/0000-0003-0691-2556)
- Liang Li (ORCID: https://orcid.org/0000-0003-0745-2571)
- Xiaoqing Wang (ORCID: https://orcid.org/0000-0001-7476-8889)
- Jie Cao (ORCID: https://orcid.org/0000-0002-0401-590X)
- Fei Wang (ORCID: https://orcid.org/0000-0001-9459-9461)
Institutions
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
- Southern Medical University (CN)
- South China University of Technology (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s12964-024-01990-3
- Citations
- 8
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 1.92
Funders
- National Natural Science Foundation of China