Changes in DNA methylation are associated with systemic lupus erythematosus flare remission and clinical subtypes
Changes in DNA methylation during active SLE were associated with remission status and identified subgroups of SLE patients with several distinct clinical and biological characteristics. DNA methylation patterns might help inform SLE subtypes, leading to targeted therapies based on relevant underlying biological pathways.
Authors
- Chun Jimmie Ye (ORCID: https://orcid.org/0000-0001-6560-3783)
- Mary Horton (ORCID: https://orcid.org/0000-0002-0854-4219)
- Jinoos Yazdany (ORCID: https://orcid.org/0000-0002-3508-4094)
- Cristina Lanata (ORCID: https://orcid.org/0000-0002-6017-4921)
- Maria Dall’Era (ORCID: https://orcid.org/0000-0001-7439-2316)
- Patricia Katz
- Joanne Nititham (ORCID: https://orcid.org/0000-0002-9972-1451)
- Kimberly E. Taylor (ORCID: https://orcid.org/0000-0001-6848-9074)
- Charlotte Hurabielle (ORCID: https://orcid.org/0000-0002-5179-5873)
- Lisa F. Barcellos (ORCID: https://orcid.org/0000-0002-0303-3479)
- Lindsey A. Criswell (ORCID: https://orcid.org/0000-0002-0761-7543)
Institutions
- National Institutes of Health (US)
- University of California, San Francisco (US)
- National Human Genome Research Institute (US)
- University of California, Berkeley (US)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s13148-024-01792-x
- Citations
- 2
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Institutes of Health
- Centers for Disease Control and Prevention
- National Human Genome Research Institute
- National Institute of Arthritis and Musculoskeletal and Skin Diseases