ZO-1 boosts the in vitro self-renewal of pre-haematopoietic stem cells from OCT4-reprogrammed human hair follicle mesenchymal stem cells through cytoskeleton remodeling
ZO-1 improved the self-renewal of pre-HSCs from OCT4-overexpressing hHFMSCs by remodeling the cytoskeleton via the ZO-1-regulated AJ pathway, suggesting floating hHFMSCs<sup>OCT4</sup> as the promising seed cells for artificial hematopoiesis.
Authors
- Zhijing Liu (ORCID: https://orcid.org/0000-0003-3489-2310)
- Pengpeng Sun (ORCID: https://orcid.org/0000-0002-8106-5978)
- Yingchun Ruan
- Xiaozhen Yu (ORCID: https://orcid.org/0000-0002-4572-8674)
- Xingang Huang
- Hua Chen (ORCID: https://orcid.org/0000-0002-9829-6561)
- Xiaohua Tan (ORCID: https://orcid.org/0000-0003-0079-8254)
- Yaolin Song
Institutions
- Qingdao University (CN)
- Affiliated Hospital of Qingdao University (CN)
- Qingdao Municipal Hospital (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s13287-024-04080-w
- Citations
- 3
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 1.31
Funders
- Natural Science Foundation of Shandong Province
- Qingdao Municipal Science and Technology Bureau