Glabridin exhibits potent inhibitory effects against Toxoplasma gondii in vitro and in vivo
This study demonstrates that glabridin has potent anti-T. gondii effects in vitro and in vivo, likely through disruption of amino acid metabolism in the parasite. These findings highlight glabridin's potential as a promising therapeutic agent for toxoplasmosis.
Authors
- Xing‐Quan Zhu (ORCID: https://orcid.org/0000-0003-2530-4628)
- Xiao-Nan Zheng (ORCID: https://orcid.org/0009-0004-6224-3603)
- Hany M. Elsheikha (ORCID: https://orcid.org/0000-0003-3303-930X)
- Hai-Ting Guo
- Bintao Zhai (ORCID: https://orcid.org/0000-0002-6378-2527)
- Chun‐Xue Zhou (ORCID: https://orcid.org/0009-0007-5878-138X)
- Chen Wang (ORCID: https://orcid.org/0000-0002-2132-0869)
- Lu Wang (ORCID: https://orcid.org/0000-0003-1535-8411)
Institutions
- Shanxi Agricultural University (CN)
- University of Nottingham (GB)
- Shandong University (CN)
- Guilin Medical University (CN)
- Guangxi Academy of Special Crops (CN)
- Lanzhou Institute of Husbandry and Pharmaceutical Sciences (CN)
- Chinese Academy of Agricultural Sciences (CN)
- Ministry of Agriculture and Rural Affairs (CN)
Publication Details
- Journal
- Parasites & Vectors
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s13071-024-06610-0
- Citations
- 4
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Shanxi Agricultural University
- Bijzonder Onderzoeksfonds UGent
- National Key Research and Development Program of China