Glutamine-αKG axis affects dentin regeneration and regulates osteo/odontogenic differentiation of mesenchymal adult stem cells via IGF2 m6A modification
Our findings indicate that glutamine-αKG axis may epigenetically promote osteo/odontogenic differentiation of dental-pulp-derived m-ASCs and dentin regeneration, which provide a new research vision of potential dental tissue repairment therapy method or metabolite-based drug research.
Authors
- Yachuan Zhou (ORCID: https://orcid.org/0000-0002-5940-5534)
- Qinglu Tian (ORCID: https://orcid.org/0000-0002-0897-4024)
- Liwei Zheng (ORCID: https://orcid.org/0000-0002-0467-1720)
- S.-H. LI (ORCID: https://orcid.org/0009-0005-3210-0553)
- Xuedong Zhou (ORCID: https://orcid.org/0000-0002-9319-7302)
- Shiqi Gao (ORCID: https://orcid.org/0000-0003-1572-7715)
- Mian Wan (ORCID: https://orcid.org/0000-0002-9245-5867)
- Xin Zhou (ORCID: https://orcid.org/0000-0002-7041-2647)
- Wei Du (ORCID: https://orcid.org/0000-0002-8333-0069)
Institutions
- Sichuan University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s13287-024-04092-6
- Citations
- 3
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- National Natural Science Foundation of China
- Sichuan University
- West China Hospital, Sichuan University