Epigenome-wide mediation analysis of the relationship between psychosocial stress and cardiometabolic risk factors in the Health and Retirement Study (HRS)
A subset of the mediating CpG sites were associated with the expression of genes enriched in pathways related to cytokine binding and receptor activity, as well as neuron development. Findings from this study help to elucidate the underlying mechanisms through which DNA methylation partially mediates the relationship between psychosocial stress and cardiometabolic risk factors.
Authors
- Lauren Opsasnick (ORCID: https://orcid.org/0000-0001-6345-7276)
- Lauren Schmitz (ORCID: https://orcid.org/0000-0002-1641-289X)
- Belinda L. Needham (ORCID: https://orcid.org/0000-0001-5939-2027)
- Xiang Zhou (ORCID: https://orcid.org/0000-0002-4331-7599)
- Scott M. Ratliff (ORCID: https://orcid.org/0000-0002-6109-662X)
- Jennifer A. Smith (ORCID: https://orcid.org/0000-0002-3575-5468)
- Jiacong Du (ORCID: https://orcid.org/0000-0002-7768-9083)
- Jessica D. Faul (ORCID: https://orcid.org/0000-0002-6969-6478)
- Wei Zhao (ORCID: https://orcid.org/0000-0002-4032-5745)
Institutions
- University of Wisconsin–Madison (US)
- University of Michigan (US)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s13148-024-01799-4
- Citations
- 5
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- National Institutes of Health
- National Institute on Aging
- National Heart, Lung, and Blood Institute
- National Human Genome Research Institute