Transcriptomic and proteomic sequencing unveils the role of vitamin D and metabolic flux shifts in the induction of human hepatic organoids
We elucidated a pivotal role for calcitriol in facilitating the transition from FG to HB by activating VDR and augmenting the expression of critical transcription factors (TFs). Besides, our research underscores a shift in metabolic pathways toward glycolytic energy metabolism in HO2 organoids. Overall, our multiomics approach reveals the intricate molecular regulation during the development of HOs.
Authors
- Qing Shi (ORCID: https://orcid.org/0000-0003-0690-7669)
- Xiuli Ju (ORCID: https://orcid.org/0000-0001-5464-3106)
- Linghong Liu (ORCID: https://orcid.org/0000-0003-2637-0408)
- Dong Li (ORCID: https://orcid.org/0000-0002-6496-4605)
- Shule Zhang
- Xianyu Li (ORCID: https://orcid.org/0000-0002-2824-7983)
- Tiancheng Zhou
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Guangzhou Institutes of Biomedicine and Health (CN)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s13287-024-04101-8
- Citations
- 4
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 1.48
Funders
- Jinan Science and Technology Bureau
- Shandong University
- Natural Science Foundation of Shandong Province