Multiomics analyses reveal adipose-derived stem cells inhibit the inflammatory response of M1-like macrophages through secreting lactate
Our results showed that ADSCs suppress pro-inflammatory effects of M1-like macrophages by secreting lactate. This study adds to our understanding of the importance of metabolites and is also expected to elucidate new mechanisms of ADSC treatments.
Authors
- Yoshiyuki Tachi
- Ikuhiro Tanida
- Naoki Yamamoto
- Toru Ichiseki (ORCID: https://orcid.org/0000-0002-6361-9615)
- Yumi Sunatani (ORCID: https://orcid.org/0000-0002-7227-0064)
- Atsushi Fuku (ORCID: https://orcid.org/0000-0001-7229-4974)
- Tetsuhiro Horie (ORCID: https://orcid.org/0000-0002-2095-9425)
- Ayumi Kaneuji (ORCID: https://orcid.org/0000-0001-7224-0722)
- Yasuhito Ishigaki (ORCID: https://orcid.org/0000-0003-1012-8430)
- Hironori Kitajima (ORCID: https://orcid.org/0000-0002-5285-9429)
- Norio Kawahara (ORCID: https://orcid.org/0000-0002-4348-897X)
- Hiroshi Sunami (ORCID: https://orcid.org/0000-0001-7550-8050)
- Takuya Sakamoto (ORCID: https://orcid.org/0000-0003-2519-4510)
- Satoshi Osawa (ORCID: https://orcid.org/0000-0003-3414-1808)
- Kuniyoshi Iwabuchi (ORCID: https://orcid.org/0000-0003-2966-3732)
- Yusuke Shimizu (ORCID: https://orcid.org/0000-0002-2528-2003)
- Hiroaki Hirata (ORCID: https://orcid.org/0000-0002-2604-9158)
- Yuka Nakamura (ORCID: https://orcid.org/0000-0002-4803-2111)
Institutions
- Kanazawa Institute of Technology (JP)
- Fujita Health University (JP)
- Kanazawa Medical University (JP)
- University of the Ryukyus (JP)
- Kanazawa Medical University Hospital (JP)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s13287-024-04072-w
- Citations
- 5
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.20
Funders
- Nakatomi Foundation
- Shibuya Science Culture and Sports Foundation
- Kanazawa Medical University
- University of Tokyo
- Japan Society for the Promotion of Science