Functional omics of ORP7 in primary endothelial cells
The transcriptomics results suggest an increase in prostanoid as well as oxysterol synthesis, which could be related to the observed upregulation of proinflammatory genes. We envision that the defective angiogenesis in HUVECs subjected to ORP7 inhibition could be the result of an unfavorable plasma membrane lipid composition and/or reduced potential for cell division. To conclude, the present study suggests multifaceted functions of ORP7 in lipid homeostasis, angiogenic tube formation, and gene expression of lipid metabolism, inflammation, and cell cycle in primary endothelial cells.
Authors
- Hanna Ruhanen (ORCID: https://orcid.org/0000-0002-9882-6817)
- J. Taskinen
- Minna Holopainen (ORCID: https://orcid.org/0000-0002-3030-8677)
- Salla Keskitalo (ORCID: https://orcid.org/0000-0001-5555-1975)
- Elina Ikonen (ORCID: https://orcid.org/0000-0001-8382-1135)
- Vesa M. Olkkonen (ORCID: https://orcid.org/0000-0001-5553-7997)
- Reijo Käkelä (ORCID: https://orcid.org/0000-0003-4953-3062)
- Miesje M. van der Stoel (ORCID: https://orcid.org/0000-0003-4245-2497)
- Markku Varjosalo (ORCID: https://orcid.org/0000-0002-1340-9732)
Institutions
- University of Helsinki (FI)
- Minerva Foundation (FI)
- Finland University (FI)
- Biocenter Finland (FI)
- Cancer Society of Finland (FI)
Publication Details
- Journal
- BMC Biology
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s12915-024-02087-6
- Citations
- 2
- Primary Topic
- Cholesterol and Lipid Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.15
Funders
- Helsingin Yliopisto
- Minerva Foundation
- National Institutes of Health