FAM96B negatively regulates FOSL1 to modulate the osteogenic differentiation and regeneration of periodontal ligament stem cells via ferroptosis
FAM96B depletion promoted the osteogenic differentiation and suppressed the ferroptosis of PDLSCs. FAM96B negatively regulated the downstream gene FOSL1 and FOSL1 promoted the osteogenic differentiation of PDLSCs via the ferroptosis. Hence, our findings provided a foundation for understanding the FAM96B-FOSL1 axis acting as a target for MSC mediated bone regeneration.
Authors
- Yiping Huang (ORCID: https://orcid.org/0000-0003-2263-0612)
- Qianyi Qin (ORCID: https://orcid.org/0000-0002-0713-6336)
- Runzhi Guo (ORCID: https://orcid.org/0000-0002-2232-1396)
- Haoqing Yang (ORCID: https://orcid.org/0000-0003-1662-9420)
- Yunfei Zheng (ORCID: https://orcid.org/0000-0003-1899-8051)
- Luyuan Jin (ORCID: https://orcid.org/0000-0002-0556-2593)
- Weiran Li (ORCID: https://orcid.org/0000-0001-9895-1143)
- Zhipeng Fan
Institutions
- King University (US)
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Stomatology Hospital (CN)
- Cells Therapy (Poland) (PL)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s13287-024-04083-7
- Citations
- 8
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China