Pediatric SARS-CoV-2 long term outcomes study (PECOS): cross sectional analysis at baseline
gov Identifier: NCT04830852 IMPACT: This study establishes a large, diverse, prospective, longitudinal, multi-center cohort of children with history of SARS-CoV-2 infection compared to an uninfected cohort to be followed for 3 years. Cross-sectional cohort analysis at study entry showed infected participants were more likely to report constitutional, respiratory, and GI symptoms compared to uninfected controls. Infected participants were more likely to have significantly worse parent-reported performance in 6 of 10 Patient Reported Outcome Measures domains. Continued study of this cohort will help identify clinical sequelae of COVID-19, characterize the immune response to SARS-CoV-2 infection, and identify potential genetic/immunologic factors associated with long-term outcomes.
Authors
- Robin Dewar (ORCID: https://orcid.org/0000-0002-7840-3155)
- James E. Bost
- Catherine Rehm (ORCID: https://orcid.org/0000-0003-2049-5824)
- Vandana Sachdev (ORCID: https://orcid.org/0000-0002-1168-5055)
- Sanchita Basu Das (ORCID: https://orcid.org/0000-0002-2246-7942)
- Lauren Arrigoni (ORCID: https://orcid.org/0000-0001-8679-6422)
- Arthur Ko (ORCID: https://orcid.org/0000-0002-1523-7225)
- Luigi Daniele Notarangelo (ORCID: https://orcid.org/0000-0002-8335-0262)
- Sabrina Huq (ORCID: https://orcid.org/0000-0002-4226-2549)
- Alexandra B. Yonts (ORCID: https://orcid.org/0000-0001-7290-3258)
- Karyl S. Barron (ORCID: https://orcid.org/0000-0002-6925-6130)
- Markus Wolff (ORCID: https://orcid.org/0000-0001-5640-0888)
- Eric J. N. Vilain (ORCID: https://orcid.org/0000-0002-5557-3709)
- Karen Carlyle
- Thomas R. Burklow
- Ashraf S. Harahsheh (ORCID: https://orcid.org/0000-0002-2622-573X)
- Audrey Thurm (ORCID: https://orcid.org/0000-0002-0489-9485)
- Kevin Rubenstein (ORCID: https://orcid.org/0000-0003-3516-5932)
- W. Patricia Bandettini (ORCID: https://orcid.org/0000-0003-2342-5637)
- Jacqui White (ORCID: https://orcid.org/0000-0001-7698-1552)
- Maureen Monaghan (ORCID: https://orcid.org/0000-0003-1350-7401)
- Evrim Türkbey (ORCID: https://orcid.org/0000-0002-5216-3528)
- Jonathan Zember (ORCID: https://orcid.org/0000-0002-6522-4713)
- Craig Sable (ORCID: https://orcid.org/0000-0002-6798-2737)
- David Wessel
- Shera Weyers
- Roberta L. DeBiasi (ORCID: https://orcid.org/0000-0002-5854-8875)
- Rachel Falik
- Meghan Delaney (ORCID: https://orcid.org/0000-0003-1089-5787)
- Andrew Lipton
- Laura Olivieri
- Chen Liang (ORCID: https://orcid.org/0000-0002-9803-9880)
- Uyen Truong (ORCID: https://orcid.org/0000-0002-5546-9266)
- Marcin Gierdalski (ORCID: https://orcid.org/0000-0002-4429-7825)
- Andy M. Williams (ORCID: https://orcid.org/0000-0001-6756-2751)
- Anastassios C. Koumbourlis (ORCID: https://orcid.org/0000-0002-4400-4885)
- Andrew Dixon (ORCID: https://orcid.org/0000-0003-4722-3298)
- Arlette Ndour
- Marcus Y. Chen (ORCID: https://orcid.org/0000-0003-0743-9369)
- Bernard Boateng
- Dorothy Bulas (ORCID: https://orcid.org/0000-0001-5003-2105)
- Linda Herbert (ORCID: https://orcid.org/0000-0002-8947-6931)
- Msayyadi Indiana.Edu Msayyadi Indiana.Edu
- Stephanie R. Lacey (ORCID: https://orcid.org/0009-0003-3046-9141)
- Gadwyn Sánchez
- Dinesh K. Pillai
- Jeroen Highbarger
- Mark L. Batshaw
- Monika L. Geslak
- Mallory C. Barrix
Institutions
- National Institutes of Health (US)
- Children's National (US)
- George Washington University (US)
- University of California, Irvine (US)
- Clinical Research Institute (US)
- National Heart, Lung, and Blood Institute (US)
- National Research Institute (US)
- Children's Hospital of Pittsburgh (US)
- Frederick National Laboratory for Cancer Research (US)
- National Institute of Allergy and Infectious Diseases (US)
- National Cancer Institute (US)
- Office of Extramural Research (US)
- National Institute of Mental Health (US)
Publication Details
- Journal
- Pediatric Research
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1038/s41390-024-03777-1
- Citations
- 2
- Primary Topic
- Long-Term Effects of COVID-19
- Type
- article
- Field-Weighted Citation Impact
- 0.74
Funders
- U.S. Department of Health and Human Services
- Children's National Hospital
- National Institutes of Health
- National Cancer Institute
- National Institute of Allergy and Infectious Diseases
- NIH Clinical Center
- NHLBI Division of Intramural Research