CaV3.2 T-type calcium channels contribute to CGRP- induced allodynia in a rodent model of experimental migraine
The present study suggests that CGRP modulates Ca<sub>V</sub>3.2 in the TG, an effect possibly mediated by the canonical CGRP receptor and PKA activation. The increase in T-type currents in the TG may represent a contributing factor for the initiation and maintenance of the headache pain during migraine.
Authors
- Juliana Geremias Chichorro (ORCID: https://orcid.org/0000-0001-5345-141X)
- Sun Huang (ORCID: https://orcid.org/0009-0005-0563-8956)
- Ivana A. Souza (ORCID: https://orcid.org/0000-0001-6410-7622)
- Eder Gambeta (ORCID: https://orcid.org/0000-0002-0618-9110)
- Gerald W. Zamponi (ORCID: https://orcid.org/0000-0002-0644-9066)
- Darciane Favero Baggio (ORCID: https://orcid.org/0000-0001-5915-4774)
Institutions
- University of Calgary (CA)
- Alberta Children's Hospital (CA)
- Universidade Federal do Paraná (BR)
Publication Details
- Journal
- The Journal of Headache and Pain
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s10194-024-01921-0
- Citations
- 7
- Primary Topic
- Migraine and Headache Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.70
Funders
- University of Otago
- Canada Research Chairs