Meis transcription factors regulate cardiac conduction system development and adult function
Our study identifies Meis TFs as essential regulators of the establishment of cardiac conduction function during development and its maintenance during adult life. In addition, we generated animal models and identified molecular alterations that will ease the study of Meis-associated conduction defects and congenital malformations in humans.
Authors
- Isaac Esteban (ORCID: https://orcid.org/0000-0003-3530-1850)
- Vanessa Cadenas
- Miguel Torres (ORCID: https://orcid.org/0000-0003-0906-4767)
- Juliane Winkelmann (ORCID: https://orcid.org/0000-0003-2667-9691)
- A. Ludwig (ORCID: https://orcid.org/0000-0002-1548-4621)
- Ana Simón-Chica (ORCID: https://orcid.org/0000-0002-0664-0397)
- Veronika Olejníčková (ORCID: https://orcid.org/0000-0002-0991-1420)
- David Filgueiras‐Rama
- Noelia Muñoz-Martín
- Susana Temiño
- David Sedmera (ORCID: https://orcid.org/0000-0002-6828-3671)
- Barbara Schormair (ORCID: https://orcid.org/0000-0003-0942-5243)
- Covadonga Díaz-Díaz (ORCID: https://orcid.org/0000-0003-2030-6456)
Institutions
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Charles University (CZ)
- Spanish National Centre for Cardiovascular Research (ES)
- Helmholtz Zentrum München (DE)
- Centro de Investigación en Red en Enfermedades Cardiovasculares (ES)
- Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (ES)
- Centro de Investigación Biomédica en Red (ES)
- Spanish National Centre for Cardiovascular Research (ES)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1093/cvr/cvae258
- Citations
- 5
- Primary Topic
- Congenital heart defects research
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- Comunidad de Madrid
- Grantová Agentura České Republiky
- Ministerio de Ciencia e Innovación
- Centro Nacional de Investigaciones Cardiovasculares
- Horizon 2020 Framework Programme
- Agencia Estatal de Investigación