Frontal White Matter Changes and Craving Recovery in Inpatients With Heroin Use Disorder
This cohort study of inpatients with HUD on medication-assisted treatment found whole-brain normalization of structural connectivity in frontal white matter pathways implicated in emotional regulation and top-down executive control. Observed associations with decreases in baseline craving further support the possibility of recovery, highlighting the relevance of these white matter markers to a major symptom of addiction, with implications for clinical outcome monitoring.
Authors
- Greg Kronberg (ORCID: https://orcid.org/0000-0001-6765-3864)
- Sarah G. King (ORCID: https://orcid.org/0000-0001-8082-826X)
- Pierre‐Olivier Gaudreault
- Yuefeng Huang (ORCID: https://orcid.org/0000-0003-2978-9087)
- Rita Z. Goldstein (ORCID: https://orcid.org/0000-0002-1680-229X)
- Ahmet O. Ceceli (ORCID: https://orcid.org/0000-0002-4897-3990)
- Nelly Alia‐Klein (ORCID: https://orcid.org/0000-0003-1876-8133)
Institutions
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1001/jamanetworkopen.2024.51678
- Citations
- 4
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.62